|
Chỉ định và Liều dùng
Intramuscular
Prophylaxis of Haemophilus influenzae type B disease in children Child: Primary immunisation: ActHIB, Hiberix 3 doses of 0.5 mL each, given at 2, 4, 6 months of age. Booster: ActHIB 15-18 months; Hiberix 12 months: 0.5 mL as a single dose. Primary immunisation: PedvaxHIB 2 doses of 0.5 mL each, given at 2, 4 months of age. Booster: 12-15 months 0.5 mL as a single dose.
|
|
Chống chỉ định
Hypersensitivity. Acute severe febrile illness.
|
|
Thận trọng
Patient with moderate or severe acute illness (with or without fever), bleeding disorders (including thrombocytopaenia), severe immunosuppression. Children. Pregnancy and lactation. Postpone vaccination in case of febrile or acute disease. Not intended for the treatment of Haemophilus influenzae infections.
|
|
Tác dụng không mong muốn
Significant: Anaphylactoid/hypersensitivity reactions, syncope.
Gastrointestinal disorders: Nausea, vomiting, diarrhoea. General disorders and administration site conditions: Inj site reactions (e.g. pain, redness, bruising, swelling); fever, irritability, fatigue. Infections and infestations: Conjunctivitis, otitis media. Metabolism and nutrition disorders: Loss of appetite. Psychiatric disorders: Somnolence, nervousness. Respiratory, thoracic and mediastinal disorders: Upper respiratory tract infection. Skin and subcutaneous tissue disorders: Rash. |
|
Parenteral: C
|
|
Chỉ số theo dõi
Monitor for hypersensitivity reactions, 15 minutes after administration.
|
|
Tương tác
Increased risk of bleeding with anticoagulants. Decreased therapeutic effect and immune response with immunosuppressive therapies (e.g. high dose corticosteroids).
|
|
Ảnh hưởng đến kết quả xét nghiệm
May interfere with interpretation of urine antigen detection tests.
|
|
Tác dụng
Description:
Mechanism of Action: Haemophilus b (Hib) conjugate vaccine (meningococcal protein conjugate) provides active immunity by inducing production of anticapsular antibodies that protect against infection caused by H. influenzae type b. Onset: Immunity: Approx 2 weeks. Duration: Immunity: Antibody concentration >1 mcg/mL: Several years. |
|
Bảo quản
Store between 2-8°C. Do not freeze. Protect from light.
Any unused portions should be disposed of in accordance with local requirements.
|
|
Phân loại MIMS
|
|
Phân loại ATC
J07AG - Haemophilus influenzae B vaccines ; Used for active immunizations.
|
|
Tài liệu tham khảo
ActHIB (Sanofi Pasteur Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/09/2018. Anon. Haemophilus b Conjugate Vaccine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 31/07/2018. Anon. Haemophilus b Vaccine. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 31/07/2018. Buckingham R (ed). Haemophilus Influenzae Vaccines. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 31/07/2018. PedvaxHIB (Merck Sharp & Dohme Corp.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 31/07/2018.
|
Đăng xuất
